Muraleedharan Nair

Muraleedharan G. Nair

Contact Me

Professor
Department of Horticulture

Phone:
(517) 353-0406

Cellphone:
517-449-7099

Email:
nairm@msu.edu

Quick links: Publications Research

Expertise and Research Interests

Our research program addresses all aspects of discovery, isolation, and identification of phytochemicals with potential as nutritional/functional food agents and phytomedicines to manage or treat diseases such as cancer, neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), musculoskeletal diseases, obesity, type-2 diabetes, inflammation and parasitic/microbial diseases. Product discovery including efficacy, toxicity, mode of action and dosage of identified phytochemical(s) to facilitate commercialization of such products as functional food constituents/nuraceuticals and phytomedicines is an integtral part of our research program. The phytochemicals of interest are also being evaluated for animal and plant health. Therefore, the core of our research is bioassay-directed discovery, purification and chemical characterization of natural products using anticancer, antioxidant, anti-diabetic, anti-inflammatory, antifungal, antibacterial, nematicidal and insecticidal assays. We also investigate bioactive phytochemicals in food and generally regarded as safe plants (GRAS) to enhance food safety and functional food value of the fresh and processed foods. Other elements of our reaserch are structure and structure activity relationships of natural products with potential to be developed as alternative medicines/botanical drugs, efficacy, toxicity and dosage of bioactive ingredients in food and GRAS plants and process development for the production of bioactive extracts/compounds for commercialization.

Summary of Expertise

Dr. Nair is a Professor in the Department of Horticulture at Michigan State University. He is an accomplished natural products chemist with extensive experience in mechanism-based bioassays and extraction, isolation, purification, structure elucidation and chemical synthesis of natural products. Dr. Nair is a Fellow of the Royal Society of Chemistry (FRSC) and Chartered Chemist (CChem), UK, a Distinguished Faculty of the College of Agriculture and Natural Resources (CANR) at Michigan State University and Member of the National Academy of Inventors, USA. He is also a Charter Member of the Farm Lane Society of the CANR Alumni Association at MSU. He served as the Senior Associate to the Dean of the MSU College of Agriculture and Natural Resources, Visiting Professor at King Saud University, Riyadh, Saudi Arabia, and coordinated the Middle East and South Asian Platform in the College of Agriculture and Natural Resources at Michigan State University. His laboratory conducts bioassay-directed discovery of bioactive natural products from plant, microbes and marine organisms. He taught chemistry for about 12 years at undergraduate level in Jamaica and India. Dr. Nair hosted and mentored numerous international researchers, professors, post-doctoral fellows, MS and Ph.D. students and is actively involved in promoting and conducting natural products research internationally. He is involved in the Academic Governance at Michigan State University, peer reviewer of numerous scientific journals, reviewer of state, federal and international funding agencies, Editorial and Advisory Board Member of several scientific journals; author or co-author of more than 230 peer-reviewed scientific journal articles, 150 published scientific abstracts, inventor or co-inventor of more than 54 US patents and 34 international patents. He was the founder, partner and President and CEO of Natural Product Technologies, LLC. and VAMTech LLC., later sold to Plant Health Care Inc., Chief Technology Officer of PhytoHealth, LLC, and V-PET Plc., Kerala, India. Currently, he is the founder, partner and Chief Technology Officer of Natural Therapeutics, LLC. in Ann Arbor, Michigan and partner of Nail17, LLC. Dr. Nair is an experienced reseasrcher in applied and basic research on bioactive natural products and its commercialization. For example, he spearheaded the Michigan tart cherry research and it led to several cherry products with health-benefits. Agricultural products that are sold in the market under trade names Mycoform® and Myconate® are technologies developed in his laboratory at MSU. A natural product combination developed in his laboratory is in the market to treat onychomycosis or toe-nail fungal disease. Another natural product developed in his laboratory is under evaluation to treat Alzheimer’s disease (AD).

Editorial Board Member of Phytomedicine; Editorial Board Member of Phytochemical Analysis; Editorial Advisory Board of Pesticide Research Journal; Editorial Board Member of Agriculture; Editorial Advisory Board of Journal of Spices and Aromatic Herbs; Reviewer of a number of scientific journals; Reviewer for national, state, university and international funding agencies.

President and Director of Research, Natural Products Technologies, Inc., 1990-2004; President & CEO, VAMTech, LLC., 1996-2004; Chief Technology Officer, Natural Therapeutics LLC, 2004-

Memberships

American Chemical Society; American Society of Pharmacognosy; Indian Association for Cancer Research; Royal Society of Chemistry; Charter Member Farm Lane Society, College of Agriculture and Natural Resources Alumni Association

Honors and Awards

National Academy of Inventors; Chartered Chemist (CChem.); Felow of the Royal Society of Chemistry (FRSC); Distinguished Faculty, College of Agriculture and Natural Resources, Michigan State University,

Farm Lane Society Charter member, MSU CANR Alumni Association

Previous Positions

1984-1987, Research Associate, Plant Cell Research Institute, Dublin California, ARCO
1979-1984, Senior Teacher, St. George's College, Kingston, Chemistry
1975-1979, Senior Teacher, Vere Technical Institute, Hayes, Clarendon, Jamaica

Patents

USA:

J.B. Mudd, J. Fobes, B. A. Burke and M. G. Nair. 2,3,4-Triacylhexoses and mixtures thereof.. US Patent No. 4,745,186. 1988.
B. A. Burke and M. G. Nair. Nonanol/Nonene derivatives of 1,2-alkyledendioxybenzenes as agrochemical microbiocides. US Patent No. 4,803,290. 1989.
B. A. Burke and M. G. Nair. Antimicrobial-antifungal compositions. US Patent No. 4,876,277. 1989.
A. R. Putnam, S. K. Mishra and M. G. Nair. Production, isolation, and identification of novel antifungal compounds. US Patent No. 4,977,084. 1990.
G. R. Safir, M. G. Nair and J. O. Siqueira. Method and compositions for stimulating vesicular-arbuscular mycorrhizal fungi.. US Patent No. 5,002,603. 1991.
S. K. Ries, V. Wert and M. G. Nair. Method for stimulating plant growth using synthetically produced 9-ß-L(+) adenosine. US Patent No. 5,009,698. 1991.
A. R. Putnam, S. K. Mishra and M. G. Nair. Production, isolation, and identification of novel antifungal compounds. US Patent No. 5,013,549. 1991.
A. R. Putnam, S. K. Mishra and M. G. Nair. Method of inhibiting fungus using novel antifungal compounds. US Patent No. 5,066,585. 1991.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Method and compositions for stimulating vesicular-arbuscular Mycorrhiza fungi. US Patent No. 5,085,682.1992.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Method and compositions for stimulating vesicular-arbuscular mycorrhiza fungi. US Patent No. 5,125,955. 1992.
M. G. Nair. Method for controlling insects. US Patent No. 5,236,949. 1993.
M. G. Nair. Method for controlling nematodes. US Patent No. 5,250,566. 1993.
M. G. Nair. Process for the isolation and purification of taxol and taxanes from Taxus spp. U.S. Patent No, 5,279,949. 1994.
M. G. Nair. Method for controlling nematodes. US Patent No. 5,310,754. 1994.
M. G. Nair. Method for controlling nematodes. US Patent No. 5,360,918. 1994.
M. G. Nair. Process for the isolation and purification of taxol and taxanes from Taxus using methanol or acetone. U.S. Patent No, 5,478,736. 1995.
M.G. Nair, J. M. Vargas, J. F. Powell, A. Chandra and A.R. Detweiler. Method for controlling fungal disease in turf grasses using Pseudomonas aureofaciens ATCC 556760. US Patent No. 5,658,794, 1997.
M.G. Nair, J. M. Vargas, J. F. Powell, A. Chandra and A.R. Detweiler. Method for controlling fungal disease in turf grasses using Pseudomonas aureofaciens ATCC 556760. US Patent No. 5,665,351, 1997.
M.G. Nair, G.R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. US Patent No. 5,691,275, 1997.
S. Balasubramanian and M. G. Nair. Process for the preparation of isoflavones. US Patent No. 5,981,775, 1999.
J. I. Gray, A.M. Booren, M. G. Nair, G. M. Strasburg, H. Wang, E. Gomaa and Y-C. Chang. Method and compositions for inhibiting oxidation. US Patent No. 5,985,636, 1999.
J. I. Gray, A.M. Booren, M. G. Nair, G. M. Strasburg, H. Wang, E. Gomaa and Y-C. Chang. Method and compositions for inhibiting oxidation. US Patent No. 5,993,881, 1999.
M. G. Nair, H. Wang, G. M. Strasburg, A.M. Booren and J. I. Gray. Tart cherry compounds that have antioxidant activity and uses thereof. US Patent No. 6,150,408, 2000.
M. G. Nair, H. Wang, G. M. Strasburg, A.M. Booren and J. I. Gray. Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids. US Patent No. 6,194,469, 2001.
M. G. Nair, R. S. Ramsewak, S. K. King, M. Stommel and L.C. Selanders. Pharmaceutical compositions containing essential oils for treatment of fungal nail disease. US Patent No. 6,344,190, 2002.
A. R. Detweiler, J. M. Vargas, N. M. Dykema and M. G. Nair. Method for inhibiting pathogenic fungi and bacteria in plants using Pseudomonas aureofaciens. US Patent No. 6,348,193, 2002.
M.G. Nair, R. S. Ramsewak, S. K. King, M. Stommel and L.C. Selanders. Pharmaceutical compositions containing essential oils for treatment of fungal nail disease. US Patent No. 6,361,785, 2002.
M.G. Nair. Method and compositions producing cherry derived products. US Patent No. 6,423,365, 2002.
M.G. Nair, H. Wang, G.M. Strasburg, A.M. Booren and J.I. Gray. Method for inhibiting inflammation using bioflavonoids. US Patent No. 6,576,271, 2003.
M.G. Nair, H. Wang, G.M. Strasburg, A.M. Booren and J.I. Gray. Method for the use of cherry isolates providing antioxidant phytoceutical or nutraceutical benefits. US Patent No. 6,623,743, 2003.
M.G. Nair, L.D. Bourquin, N.P. Seeram and S-Y. Kang. Method for treating tumors caused by APC gene mutations with anthocyanins and cyanidin. US Patent No. 6,656,914, 2003.
M.G. Nair. Method and compositions for producing berry derived products. US Patent No. 6,676,978, 2004.
R. H. Cichewicz, M.G. Nair and J. H. McKerrow. Antihelminthic anthraquinones and method of use thereof. US Patent No. 6,800615, 2004.
M. G. Nair, H. Wang, D. L. DeWitt, D. Krempin, D. K. Mody, Y.Qian, D.G. Groh, A.J. Davies, M.A. Murray, R. Dykhouse and M. Lemay. Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation. US Patent No. 6,818,234, 2004.
R. H. Cichewicz, M.G. Nair and J. H. McKerrow. Antihelminthic anthraquinones and method of use thereof. US Patent No. 6,838,443, Jan 4, 2005.
M.G. Nair, R. H. Cichewicz, N. P. Seeram and Y. Zhang. Anticancer anthraquinones and method of use thereof. US Patent No. 6,875,746, April 5, 2005.
R. H. Cichewicz, M.G. Nair and J.H. McKerrow. Antihelminthic anthraquinones and method of use thereof. US Patent No. 6,903,076, June 7, 2005.
M. Amaranthus, T. Reid and M.G. Nair. Method and composition for tree root colonization. US Patent No. 7,000,348, February 21, 2006.
R. H. Cichewicz, M.G. Nair and J.H. McKerrow. Antihelminthic anthraquinones and method of use thereof. US Patent No. 7, 132, 403, Nov. 7, 2006.
M.G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7, 141,253, Nov. 28, 2006.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7, 195,784, March 27, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7, 208,182, April 24, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7, 211,277, May 1, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7,264,831, September 4, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7,264,832, September 4, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7,264,833, September 4, 2007.
M. G. Nair, B. Jayaprakasam. Cyclooxygenase-2 inhibitory withanolide compositions and method. US Patent No. 7,270,836, September 18, 2007.
M. G. Nair, B. Jayaprakasam. Withanamide and withanolide compositions and method of use thereof. US Patent No. 7,282, 593, October 16, 2007.
M. G. Nair. Carrier-free composition for the treatment of onychomycosis. US Patent No. 7,341,747, March 11, 2008.
M. G. Nair, M. R. Dhananjeyan, M. A. Kron and Y. P. Milev. Preparation of anthraquinones as endoparasiticides. US Patent No. 7,658,937, February 9, 2010.
M. G. Nair, B. Jayaprakasam, L. K. Olson. Insulin secretion by anthocyanins and anthocyanidins. US Patent No. 7,737,121, June 15, 2010.
M. G. Nair, B. Jayaprakasam, L. K. Olson, R. E. Schutzki. Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia. US Patent No. 7, 772,195 B2, August 10, 2010.
M. G. Nair, B. Jayaprakasam, L. K. Olson, R. E. Schutzki. Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia. US Patent No. 8, 198,249 B2, June 12, 2012.
M. G. Nair, D. L. Dewitt, H. Wang, D. W. Krempin, D. K. Mody, D. G. Groh, M. A. Murray, M. Lemay, Y. Qian, A. J. Davies, R. Dykhouse. Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation. US Patent No. 8,337,914 B2, December 25, 2012.
G. M. Strasburg, J. A. Mmongoyo, J. E. Linz, F. Wu, J. K. Mugula, A. A. Dissanayake, C. Zhang, J. M. Wee, M. G. Nair, D. M. Day. Compounds for inhibition of fungal mycotoxin and sporulation. US Patent No. 10, 531, 662. January 14, 2020.

International:

G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. Australia, Patent No. 639,058, 1990.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. Taiwan, Patent No. 60604, 1993.
A. R. Putnam, S. K. Mishra and M. G. Nair. Method and microorganism for the production offaeriefungin. Canadian Patent 1,337,643. 1995.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. Japan, Patent No. 2,036,076, 1996.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. Hungary, Patent No. 211,206, 1996.
M.G. Nair, G.R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Australia, Patent No. 690873, 1997.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. South Africa, Patent No. 97/0911, 1997.
M. G. Nair, J. M. Vargas, J.F. Powell, A. Chandra and A. R. Detweiler. Method for controlling fungal diseases in turfgrasses. Canada, 218,6712, 1997.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Zimbabwe, Patent No. 10/97, 1998.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. Canada, Patent No. 2,045,538, 1998.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. China, Patent No. 42124, 1998.
M. G. Nair, G.R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Russia, Patent No. 2134510, 1999.
M. G. Nair, G.R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Japan, Patent No. 3045546,2000.
S. Balasubramanian and M.G. Nair. Process for the preparation of isoflavones. Korea, Patent No. 0355184, 2002.
G. R. Safir, M. G. Nair and Jose O. Siqueira. Compositions containing vesicular arbuscular mycorrhizal fungi and the culture methods thereof. China, Patent No. 79535, 2002.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Ukraine, Patent No. 44759, 2002.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Canada, Patent No. 2,213,575, 2003.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Taiwan, Patent No. 183918, 2003.
S. Balasubramanian and M.G. Nair. Process for the preparation of isoflavones. Canada, Patent No. 2,306,836, 2003.
M. G. Nair, G. R. Safir, R. A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. EPC, Patent No. 0817781,2004.
M. G. Nair, H. Wang, G. M. Strasburg, A.M. Booren and J.I. Gray. Method for the use of cherry isolates providing antioxidant phytochemical or nutraceutical benefits. Korean Patent No. 441927, 2004.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Formononetina de metal alcalino y metodo de estimulacion de micorrhizal. Mexico, Patent No. 222948, 2004.
B. Sreenivasan and M.G. Nair. Process for the preparation of isoflavones. European Patent 1032568, 1-26-2005.
M. G. Nair, H. Wang, G. E. Strasburg, A. Booren and J. I. Gray. Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids. Korean Patent No. 10-0499293, June 24, 2005.
M. G. Nair, R. H. Cichewicz and J. H. McKerrow. Antihelmintic substituted anthraquinones and method of use thereof. South African Patent No. 2004/8946, November 30, 2005.
M. G. Nair. Method and compositions for producing berry derived products. Chinese Patent No. ZL 99 8 16056.3, August 16, 2006.
M. G. Nair and B. Jayaprakasam. Cyclooxygensase-2 inhibitory withanolide compositions and method. Korean Patent 10-0679367, January 30, 2007.
M. G. Nair and B. Jayaprakasam. Cyclooxygensase-2 inhibitory withanolide compositions and method. Korean Patent 10-0687380, February 20, 2007.
R. H. Cichewicz, M. G. Nair, J. H. McKerrow. Antihelmenthic anthraquinones and method of use thereof. Korean Patent 10-0707051, April 5, 2007.
M. G. Nair, G. R. Safir, R.A. Schutzki and B. A. Niemira. Alkali metal formononetin and method of mycorrhizal stimulation. Indian Patent No. 213118, December 20, 2007.
M. G. Nair, B. Jayaprakasam, L. K. Olson, S. K. Vareed. Insulin secretion by anthocyanins and anthocyanidins. Australian Patent No. 2005301315, 2008.
M. G. Nair, H. Wang, G. M. Strasburg, A.M. Booren and J. I. Gray. Bioflavonoids, anthocyanins and phenolic compounds from cherries for Inhibiting Inflammation. Canadian Patent No. 2,354,042, 2-3-2009.
M.G. Nair, B. Jayaprakasam, L. K. Olson, R. E. Schutzki. Methods and compositions for the treatment of obesity, insulin related disease and hypercholesterolemia. Indian Patent No. 241475, 7-7-2010.
M. G. Nair, B. Jayaprakasam, L. K. Olson, R. E. Schutzki. Methods and compositions for the treatment of obesity. Chinese Patent No. ZL200580025447.3, 1-30-2013.

Publications in Scientific Journals

Publications from 1986-2000

Publications1986-2000.pdf

Publications from 2000 and later

J.F. Powell, J.M. Vargas, M.G. Nair, A.R. Detweiler and A. Chandra, Management of dollar spot on creeping bentgrass with metabolites of Pseudomonas aureofaciens (TX-I). Plant Disease, 84, 19-24, 2000.
A. Arora, T.M. Byren, M.G. Nair and G. M. Strasburg. Modulation of liposonal membrane fluidity by flavonoids and isoflavonoids. Arch Biochem Biophys, 373, 102-109, 2000.
S. Balasubramanian and M.G. Nair. An efficient A one Pot synthesis of isoflavones. Synthetic Communications. 30, 469-484, 2000.
S. Balasubramanian, D. L. Ward and M.G. Nair. The first isolation and crystal structure of a boron difluoro complex (isoflavone yellow). Biologically active intermediates produced during isoflavone synthesis. Perkin Trans-I. 4, 567-570, 2000.
J.E.C. Miles, R. S. Ramsewak and M.G. Nair. Non-alkaloidal compounds from Delphinium elatum cv. Magic fountains flower-parts. J. Agric. Food Chem. 48, 503-506, 2000.
N. P. Seeram, A. W. Lewis, H. Jacobs, M.G. Nair, S. McLean and W.F. Reynolds. Proctoriones A-C: 2-acylcyclohexane-1,3-dione derivatives from Peperomia proctorii. J. Nat. Prod. 63, 399-402, 2000.
M.A. Kelm, M.G. Nair, G. M. Strasburg and D.L. DeWitt. Antioxidant and cyclo-oxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 7, 7-13, 2000.
H. Wang, M. G. Nair, G. M. Strasburg, Y-C Chang, A. M. Booren, J. I. Gray and D. L. DeWitt. Cyclo-oxygenase active bioflavonoids from BalatonTM tart cherry and structure their activity relationship. Phytomedicine. 7, 15-19, 2000.
R. S. Ramsewak, D.L. DeWitt and M.G. Nair. Anticancer, antioxidant and anti-inflammatory activities of curcumins I - III from Curcuma longa. Phytomedicine. 7, 303-308, 2000.
M. G. Nair, S. Balasubramanian, J. F. Kelly, R. Schutzki, P. Wenzel and A. L. Chavez. Natural products as potential soil amendments for crop improvement. In Soil Fertility, Soil Biology and Plant Nutrition Interrelationships. Eds: J.O. Siquiera and F. M.S. Moreira. Federal University of Lavras and Brazilian Soil Science Society-SBCS, 2000.
R. A. Momin, R.S. Ramsewak, and M. G. Nair. Bioactive Compounds and 1,3-di[(cis)-9-octadecenoyl]-2-[(cis,cis)-9,12-octadecadienoyl]glycerol from Apium graveolens L. Seeds. J. Agric. Food Chem. 48, 3785-3788, 2000.
P. Wenzl, A. L. Chávez, J. E. Mayer, I. M. Rao and M. G. Nair. Two dihydroxycinnamoyl quinic acid esters from roots of nutrient-deprived Brachiaria species. Phytochemistry. 55, 397-401, 2000.
A. Arora, S. Valcic, S. Cornejo, M. G. Nair, B. N. Timmermman and D. C. Leibler. Reactions of genestein with alkylperoxyl radicals. Chemical Research in Toxicology. 13, 638-645, 2000.
A. J. Erickson, R. S. Ramsewak, A. J. Smucker and M. G. Nair. Nitrification inhibitors from the roots of Leucaena leucocephala. J. Agric. Food Chem. 48, 6174-6177, 2000.
M.A. Kelm and M.G. Nair. A brief summary of biologically active compounds from Magnolia spp. Studies in Natural products Chemistry. 24, 845-873, 2000.
R. A. Momin and M. G. Nair. Mosquitocidal, nematicidal and antimicrobial compounds from Apium graveolens L. Seeds. J. Agric. Food Chem. 49, 142-145, 2001.
S. Ries, R. Baughan, M.G. Nair and R. Schutzki. Repelling animals from crops using plant extracts. HortTechnology. 11, 302-307, 2001.
J. K. Nitao, B.A. Birr, M.G. Nair, D.A. Herms and W.J. Mattson. Rapid quantification of condensed tannins with a continuous flow analyzer. J. Agric. Food Chem. 49, 2207-2214, 2001.
N. P. Seeram, R.A. Momin, L.D. Bourquin and M.G. Nair. Cyclooxygenase and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine. 8, 362-369,2001.
N. P. Seeram, L.D. Bourquin and M.G. Nair. Degradation Products of Cyanidin Glycosides from Tart Cherries and their Bioactivities. J. Agric. Food Chem. 49, 4924-4929, 2001.
R. S. Ramsewak, M.G. Nair, S. Murugesan, W.G. Mattson and J. Zasda. Antifeedant compounds and triglycerides from Dirca palustris. J. Agric. Food Chem. 49, 5852-5856,2001.
D. C. Liebler, S. Valcic, A. Arora, J.A. Burr, S. Cornejo, M.G. Nair and B. N. Timmermann. Antioxidant reactions of green tea catechins and soy isoflavones. Advances in Experimental Medicine and Biology. 500, 191-197, 2001.
R. H. Cichewicz and M.G. Nair. Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (Hemerocallis) flowers. J. Agric. Food Chem. 50, 87-91, 2002.
D. Wu, M.G. Nair and D.L. DeWitt. Novel compounds from Piper methysticum Forst (kava kava) roots and their effects on cyclooxygenase enzyme. J. Agric. Food Chem. 50, 701-705, 2002.
D. Wu, L. Yu, M.G. Nair, D. L. DeWitt and R.S. Ramsewak. Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots. Phytomedicine. 9, 41-47, 2002.
N.P. Seeram, R. Schutzki, A. Chandra, M.G. Nair. Characterization, quantification and bioactivities of anthocyanins in Cornus spp. J. Agric. Food Chem. 50, 2519-2523, 2002.
G. E. Henry, R.A. Momin, M.G. Nair and D. L. deWitt. Antioxidant and cyclooxygenase efficacies of fatty acids found in food. J. Agric. Food Chem. 50, 2231-2234, 2002.
L. J. Clifford, M.G. Nair, J. Rana and D. L. DeWitt. Cyclooxygenase and mosquitocidal alkamides from Echinacea purpurea L. (Moench). Phytomedicine. 9, 249-254, 2002.
R. A. Momin and M.G. Nair. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn seeds. Phytomedicine. 9, 312-318, 2002.
N. V. Rajesh Kumar, K. L. Joy, G. Kuttan, R.S. Ramsewak, M.G. Nair and R. Kuttan. Antitumor and anticarcinogenic activity of Phyllanthus amarus extract. J. Ethnopharmacology. 81, 17-22, 2002.
R. A. Momin and M.G. Nair. Pest managing efficacy of trans-asarone isolated from Daucus carota L. seeds. J. Agric. Food Chem. 50, 4475-4478, 2002.
N. P. Seeram and M.G. Nair. Inhibition of lipid oxidation and Structure-Activity-Related studies of dietary constituents anthocyanins, anthocyanidins and catechins. J. Agric. Food Chem. 50, 5308-5312, 2002.
R. H. Cichewicz, K-C. Lim, J. H. McKerrow and M. G. Nair. Kwanzoquinones A-G and other constituents of Hemerocallis fulva ‘Kwanzo' roots and their activity against the human pathogenic trematode Schistosoma mansoni. Tetrahedron. 58,8597-8606, 2002.
Y. Zhang, G. L. Mills and M.G. Nair. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J. Agric. Food Chem. 50, 7581-7585, 2002.
E. González de Mejía, M. Vinicio Ramírez-Mares and M.G. Nair. Topoisomerase I and II enzyme inhibitory aqueous extract of Ardisia compressa and ardisin provide antioxidant protection against benomyl-damaged hepatocytes. J. Agric. Food Chem. 50, 7714-7719, 2002.
B. Jayaprakasam, N. P. Seeram and M. G. Nair. Anticancer and antiinflamatory activities of cucurbitacins from Cucurbita andreana. Cancer Letters. 189, 11-16, 2003.
N. P. Seeram, R. H. Cichewicz, A. Chandra and M. G. Nair. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. J. Agric. Food Chem. 51, 1948-1951, 2003.
S-Y. Kang, N. P. Seeram, L. D. Bourquin and M. G. Nair. Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cells. Cancer Letters. 194, 13-19, 2003.
B. Jayaprakasam and M. G. Nair. Cyclooxygenase-2 inhibitory withanolides from Withania somnifera leaves. Tetrahedron. 59, 841-849, 2003.
R. S. Ramsewak, M. G. Nair, M. Stommel and L. Selanders. In vitro antibiotic activity of monoterpenes and their mixtures against Toe Nail Fungus pathogens. Phytotherapy Research. 17, 376-379, 2003.
Y. Zhang, G. L. Mills and M. G. Nair. Cyclooxygenase inhibitory and antioxidant compounds from the fruiting body of an edible mushroom, Agrocybe aegerita. Phytomedicine. 10, 386-390, 2003.
V. Sharma, S. Walia, J. Kumar, M. G. Nair and B.S. Parmar. An efficient method for the purification and characterization of azadirachtins A, B, and H using MPLC and ESIMS. J. Agric. Food Chem. 51, 3966-3972, 2003.
N. P. Seeram, Y. Zhang and M. G. Nair. Inhibition of proliferation of human cancer cell lines and cyclooxygenase enzymes by anthocyanidins and catechins. Nutrition and Cancer. 46, 101-106, 2003.
R. A. Momin, D. L. DeWitt and M. G. Nair. Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. Seeds. Phytotherapy Research. 17, 976-979, 2003.
B. Jayaprakasam, Y. Zhang, N. P. Seeram and M. G. Nair. Antiproliferative activity of Withania somnifera leaf components on human tumor cell lines and their structure activity relationships. Life Sciences. 74, 125-132, 2003.
B. H. Babu, H. N. Jayaram, M. G. Nair, K. B. Ajaikumar and J. Padikkala. Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. J. Exp. Clin. Cancer Res., 22, 421-429, 2003.
R. H. Cichewicz, N. P. Seeram, Y. Zhang and M. G. Nair. Anti-tumor effects of novel anthraquinones from daylilies against human cancer cell lines. Life Sciences. 74, 1791-1799, 2004.
J. A. Francis, B. Jayaprakasam, L. K. Olson and M. G. Nair. Insulin secretagogues from Moringa oleifera with cyclooxygenase and lipid peroxidation inhibitory activities. Helvetica Acta Chimica. 87, 317-326, 2004.
Y. Zhang, B. Jayaprakasam, N. P. Seeram, L. K. Olson, D. L. DeWitt and M. G. Nair. Insulin production and cyclooxygenase enzyme inhibition by Cabernet sauvignon grape skin compounds. J. Agric. Food Chem. 52, 228-233, 2004.
A.G. Beckwith, Y. Zhang, N. P. Seeram, A. C. Cameron and M. G. Nair. Relationship of light quantity and anthocyanin production in Pennisetum setaceum ‘Rubrum' and ‘Red Riding Hood'. J. Agric. Food Chem. 52, 456-461, 2004.
B. Jayaprakasam, G. M. Strasburg and M. G. Nair. Potent lipid peroxidation inhibitors from Withania somnifera fruits. Tetrahedron. 60, 3109-3121, 2004.
Y. Zhang, D. L. DeWitt, S. Murugesan and M. G. Nair. Novel lipid peroxidation and cyclooxygenase enzyme inhibitory tannins from Picrorhiza kurroa seeds. Chemistry & Biodiversity. 1, 426-441, 2004.
M. J. Weil, Y. Zhang and M. G. Nair. DEHP and colon cancer proliferating desulfosinigrin (DSS) in wasabi (Wasabia japonica). Nutrition and Cancer.48, 207-213, 2004.
Y. Zhang, R. H. Cichewicz and M. G. Nair. Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves. Life Sciences. 75, 753-763, 2004. Erratum: 75(17, 2143-2144, 2004.
R. L. Alexander-Lindo, E. Y. St. A. Morrison and M. G. Nair. Hypoglycaemic effect of stigmast-4-en-3-one and its corresponding alcohol from the bark of Anacardium occidentale (Cashew). Phytotherapy Research. 18, 403-407, 2004.
J. M. Tall, N. P. Seeram, C. Zhao, M. G. Nair, R.A. Meyer and S. N. Raja. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behavioural Brain Research. 153, 181-188, 2004.
B. Jayaprakasam, Y. Zhang and M. G. Nair. Tumor cell proliferation and cyclooxygenase enzyme inhibitory compounds in Amaranthus tricolor. J. Agric. Food Chem. 52,6939-6943,2004.
J. A. Francis, W. K. Rumbeiha and M. G. Nair. Constituents in Easter lily flowers with medicinal activity. Life Sciences. 76,671-683,2004.
W. K. Rumbeiha, J. A. Francis, S. Fitzgerald, M. G. Nair, K. Holan, K. A. Bugyei and H. Simmons. A comprehensive study of Easter lily poisoning in cats. J. Vet. Diagn. Invest. 16, 527-541, 2004.
J. A. Francis, S. N. Raja and M. G. Nair. Bioactive terpenoids and guggulusteroids from Commiphora mukul resin. Chemistry & Biodiversity. 1, 1842-1853, 2004.
P. Raman, L. C. Patino and M. G. Nair. Evaluation of metal and microbial contamination in botanical supplements. J. Agric. Food Chem. 52,7822-7827,2004.
B. Jayaprakasam, S. K. Vareed, L. K. Olson and M. G. Nair. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J. Agric. Food Chem. 53, 28-31, 2005.
Y. Zhang, S. K. Vareed and M. G. Nair. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sciences. 76, 1465-1472, 2005.
M. J. Weil, Y. Zhang and M. G. Nair. Tumor cell proliferation and cyclooxygenase enzyme inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica). J. Agric. Food Chem. 53, 1440-1444, 2005.
M. R. Dhananjeyan, Y. Milev, M. A. Kron and M. G. Nair. Synthesis and Activity of Substituted anthraquinones Against a Human Filarial Parasite, Brugia malayi. J. Med. Chem. 48, 2822-2830, 2005.
N. P. Seeram, L. S. Adams, S. M. Henning, Y. Niu, Y. Zhang, M. G. Nair and D. Heber. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochemistry. 16, 360-367, 2005.
D. P. Adhikari, J. A. Francis, R. E. Schutzki, A. Chandra and M. G. Nair. Quantification and characterization of cyclooxygenase and lipid peroxidation inhibitory anthocyanins in fruits of Amelanchier. Phytochemical analysis. 16, 175-180, 2005.
M. P. Amaranthus, M. G. Nair, T.C. Reid and D. Steinfeld. Improved Rhizopogon mycorrhizal colonization and foliar nutrient levels in ponderosa pine and Douglas-fir with Myconate. J. Sustainable Forestry. 20, 1-14, 2005.
M. K. Reddy, R. L. Alexander-Lindo and M. G. Nair. Relative inhibition of lipid peroxidation, cyclooxygenase and tumor cell proliferation by natural food colors. J. Agric. Food Chem. 53, 9268-9273, 2005.
Y. Zhang, D. L. DeWitt, S. Murugesan and M. G. Nair. Cyclooxygenase-2 enzyme inhibitory triterpenoids from Picrorhiza kurroa seeds. Life Sciences. 77, 3222-3230, 2005.
S. K. Vareed, M. K. Reddy, R. E. Schutzki and M. G. Nair. Tumor cell growth inhibitory anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida Fruits. Life Sciences. 78, 777-784, 2006.
B. Jayaprakasam, L. K. Olson, R. E. Schutzki, M-H. Tai and M. G. Nair. Amelioration of obesity and glucose intolerance in high fat fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J. Agric. Food Chemistry. 54, 243-248, 2006.
B. B. Aggarwal, H. Ichikawa, P. Garodia, P. Weerasinghe, G. Sethi, I.D. Bhatt, M. K. Pandey, S. Shishodia and M. G. Nair. From traditional Ayurvedic medicine to modern medicine: Identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin. Ther. Targets, 10, 87-118, 2006.
D. P. Adhikari, R. E. Schutzki, D. L. DeWitt and M. G. Nair. Effects of Amelanchier fruit isolates on cyclooxygenase enzymes and lipid peroxidation. Food Chemistry. 97, 56-64, 2006.
E. C. Hill, Ngouajio, M. and M. G. Nair. Differential response of weeds and vegetable crops to aqueous extracts of hairy vetch (Vicia villosa) and cowpea (Vigna unguiculata). HortScience. 41, 695-700, 2006.
H. Ichikawa, Y. Takada, S. Shishodia, B. Jayaprakasam, M. G. Nair and B. B. Aggarwal. Withanolide potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor (NF)-κB activation and NF-κB-regulated gene expression. Molecular Cancer Therapeutics. 5, 1432-1445, 2006.
B. Jayaprakasam, M. Vanisree, Y. Zhang, D. L. DeWitt and M. G. Nair. Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme and lipid peroxidation. J. Agric. Food Chem. 54, 5375-5381, 2006.
K. R. Christian, M. G. Nair, J.C. Jackson. Antioxidant and cyclooxygenase inhibitory activity of Hibiscus sabdariffa. Journal of Food Composition and Analysis. 19, 778-783, 2006.
Y. Wang, D. Botolin, J. Xu, B. Christian, B. Jayaprakasam, M. G. Nair, J. Peters, J. Bisik, L. K. Olson and D. B. Jump. Regulation of hepatic elongase and desaturase expression in diabetes and obesity. J. Lipid Res. 47, 2028-2041, 2006.
G. E. Henry, S. Raithore, Y. Zhang, B. Jayaprakasam, M. G. Nair, D. Heber and N. P. Seeram. Acylpholoroglucinol derivatives from Hypericum prolificum. J. Nat. Prod. 69, 1645-1648, 2006.
G. Bobe, B. Wang, N. P. Seeram, M. G. Nair and L. D. Bourquin. Dietary anthocyanin-rich tart cherry extract inhibit intestinal tumorigenesis in APC Min mice fed suboptimal levels of sulindac. J. Agric. Food Chem. 54, 9322-9328, 2006.
G. V. Subbaraju, V. Mulabagal, C.V. Rao, C. Sivaramakrishna, P. Sridhar, B. Jayaprakasam and M. G. Nair. Ashwagandhanolide, a novel bioactive thiowithanolide isolated from Withania somnifera roots. J. Nat. Prod. 69, 1790-1792, 2006.
S. K. Vareed, R. E. Schutzki and M. G. Nair. Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa. Phytomedicine. 14, 706-709, 2007.
E. C. Hill, Ngouajio, M. and M. G. Nair. Allelopathic potential of hairy vetch and cowpea methanol and ethyl acetate extracts on weeds and vegetables. Weed Technology. 21, 437-444, 2007.
R. L. Alexander-Lindo, E. Y. St-A. Morrison, M. G. Nair and D.A. McGrowder. Effect of the fractions of the hexane extract and stigmast-4-en-3-one isolated from Anacardium occidentale on blood glucose tolerance test in an animal model. International Journal of Pharmacology. 3, 41-47, 2007.
B. Jayaprakasam, R. L. Alexander-Lindo, D. L. DeWitt and M. G. Nair. Terpenoids from stinking toe (Hymnea courbaril) with cyclooxygenase and lipid peroxidation inhibitory activities. Food Chemistry. 105, 485-490, 2007.
V. Mulabagal, S. van Nocker, D. L. DeWitt and M. G. Nair. Cultivars of apple fruits that are not marketed with potential for anthocyanin production. J. Agric. Food Chem. 55, 8165-8169, 2007.
C. Viegas Jr., D. H. S. Silva, M. Pivatto, A. de Rezende, I. Castro-Gamboa, V. S. Bolzani and M. G. Nair. Lipoperoxidation and cyclooxygenase enzyme inhibitory piperidine alkaloids from Senna spectabilis green fruits. J. Nat. Prod. 70, 2026-2028, 2007.
D. H. S. Silva, Y. Zhang, L. A. Santos, V. S. Bolzani and M. G. Nair. Lipoperoxidation and cyclooxygenase enzymes inhibitory compounds from Iryanthera juruensis. J. Agric. Food Chem. 55, 2569-2574, 2007.
V. Mulabagal, R. L. Alexander-Lindo, D. L. DeWitt and M. G. Nair. Functional food components in Antogonin leptopus tea. Food Chemistry. 106, 487-492, 2008.
K. Georges, B. Jayaprakasam, S.S. Dalavoy and M. G. Nair. Pest-managing activities of Burkina Faso plant extracts and anthraquinones from Cassia nigricans. Bioresource Technology. 99, 2037-2045, 2008.
T. Diyabalanage, M. Vanisree, G. Mills, D. L. Dewitt and M. G. Nair. Health-beneficial qualities of edible mushroom Agrocybe aegerita. Food Chemistry. 108, 97-102, 2008.
P. Raman, D. L. DeWitt and M. G. Nair. Lipid peroxidation and cyclooxygenase enzymes inhibitory activities of acidic aqueous extracts of some dietary supplements. Phytotherapy Research. 22, 204-212, 2008.
G. F. Yu, V. Mulabagal, T. Diyabalanage, W. A. Hurtada, D. L. DeWitt and M. G. Nair. Non-nutritive functional agents in rattan-shoots consumed by native people in the Philippines. Food Chemistry. 110, 991-996, 2008.
V. Mulabagal, G. V. Subbaraju, M. Ramani, D. L. DeWitt and M. G. Nair. Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory lignans from Justicia species. Natural Product Communications. 3, 1793-1798, 2008.
E. Petrunak, A. Kester, Y. Liu, C. S. Bowen-Forbes, M. G. Nair and G. E. Henry. New Benzophenone O-Glucosides from Hypericum ellipticum. Natural Product Communications. 4, 507-510, 2009.
V. Mulabagal, G. A. Lang, D. L. Dewitt, S. A. Dalavoy and M. G. Nair. Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries. J. Agric. Food Chem. 57, 1239-1246, 2009.
C. S. Bowen-Forbes, V. Mulabagal, Y. Liu and M. G. Nair. Ursolic acid analogues: Non-phenolic functional food components in Jamaican raspberry fruits. Food Chemistry. 116, 633-637, 2009.
G. A. Logan, G. S. Howell and M. G. Nair. Cyanidin-3-O-glucoside is an important anthocyanin in several clones of Vitis vinifera L. Pinot noir fruits and resulting wine from Michigan and New Zealand. Internet Journal of Enology and Viticulture 5:2 1-12, 2009.
A. R. Kowalewski, D. D. Buhler, N. S. Lang, M. G. Nair and J. N. Rogers. Mulched maple and oakleaves associated with a reduction in common dandelion populations in established Kentucky bluegrass. HortTechnology, 19, 297-304, 2009.
V. Mulabagal, G. V. Subbaraju, C.V. Rao, C. Sivaramakrishna, D. L. DeWitt, D. Holmes, B. Sung, B. B. Aggarwal and M. G. Nair. A withanolide sulfoxide from Withania somnifera inhibits nuclear transcription factor-kappa-B, cyclooxygenase-2 and tumor cell proliferation. Phytotherapy Research. 22, 987-992, 2009.
Y. Liu, V. Mulabagal, C. S. Bowen-Forbes, R. Aviayan and M. G. Nair. Lipid peroxidation, cyclooxygenase enzyme and human tumor cell proliferation inhibitory compounds in herbal water. Molecular Nutrition & Food Research. 53,1177-1186, 2009.
V. Mulabagal, H. Wang, M. Ngouajio and M. G. Nair. Characterization and quantification of health beneficial anthocyanins in leaf chicory (Cichorium intybus) varieties. European Food Research and Technology. 230, 47-53, 2009.
T. Diyabalanage, M. Vanisree, G. Mills, D. L. Dewitt and M. G. Nair. Liperoxidation and cyclooxygenase enzyme inhibitory compounds from the lipophilic extracts of some culinary-medicinal higher Basidiomycetes mushrooms. International Journal of Medicinal Mushrooms. 4, 375-382, 2009.
G. H. Henry, M. Campbell, A. A. Zelinsky, Y. Liu, C. S. Bowen-Forbes, L. Li, M. G. Nair, D. C. Rowley and N. P. Seeram. Bioactive acylphloroglucinols from Hypericum densiflorum. Phytotherapy Research. 23, 1759-1762, 2009.
V. Mulabagal, M. Ngouajio, A. Nair, Y. Zhang, A. L. Gottumukkala and M. G. Nair. In vitro evaluation of red and green lettuce for functional food qualities. Food Chemistry. 118, 300-306, 2010.
Y. Liu and M. G. Nair. Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and anti-inflammatory activities. Natural Product Communications. 5, 91-94, 2010.
B. Jayaprakasam, K. Padmanabhan and M. G. Nair. Withanamides in Withania somnifera fruits protect PC-12 cells from β-amyloid responsible for Alzheimer's disease. Phytotherapy Research. 24, 859-863, 2010.
Y. Liu and M. G. Nair. Non-pungent functional food components in water extracts of hot peppers. Food Chemistry. 122, 731-736, 2010.
Y. Liu, V.R. Yadev, B. B. Aggarwal and M. G. Nair. Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Natural Product Communications. 8, 1253-1257, 2010.
C. S. Bowen-Forbes, Y. Zhang and M. G. Nair. Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry. Journal of Food Composition and Analysis. 23, 554-560, 2010.
R. G. Fowles, B. S. Mootoo, R. S. Ramsewak, A. Khan, A. Ramsubhag W. F. Reynolds and M. G. Nair. Identification of new limonoids from Swietenia and their biological activity against Insects. Pest Management Science. 66, 1298-1303, 2010.
Y. Liu and M. G. Nair. An efficient and economical MTT assay for determining the antioxidant activity of compounds and extracts. J. Nat. Prod. 77, 1193-1195, 2010.
Y. Liu and M. G. Nair. Labdane diterpenes in Curcuma mangga rhizomes inhibit lipid peroxidation, cyclooxygenase enzymes and human tumor cell proliferation. Food Chemistry. 124, 527-532, 2011.
V. Mulabagal, R. L. Alexander-Lindo, D. L. DeWitt and M. G. Nair. Health-beneficial phenolic aldehydes in Antigonin leptopus tea. Evidence based Complementary and Alternative medicine (eCAM). Article ID 601249, 6 pages, 2011. doi:10.1093/ecam/nep041.
R. G. Fowles, B. S. Mootoo, R. S. Ramsewak, A. Khan, A. Ramsubhag, W. F. Reynolds and M. G. Nair. Limonoids with lipid peroxidation activity. Natural Product Communication. 6, 785-787, 2011.
J. Min, S-W. Yu, S-H. Baek, K. M. Nair, OK-N. Bae, A. Bhatt, M. Kassab, M. G. Nair and A. Majid. Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. Neuroscience Letters. 500, 157-161, 2011.
F. A. Russell, W. F. Reynolds, M. A. Singh-Wilmot, V. Mulabagal, M. G. Nair and P. B. Reese. Novel stemodin-derived analogues with lipid peroxidation, cyclooxygenase enzymes and human tumor cell proliferation inhibitory activities. Phytochemistry. 72, 2361-2368, 2011.
C. Bailey, K.R. Christian, S. Pradhan, M.G. Nair and O.E. Christian. Antiinflammatory and antioxidant activity of Coccoloba uvifera (sea grapes). Current Topics in Phytochemistry, 10, 55-60, 2011.
Y. Liu, R. K. Kakani, M. G. Nair. Compounds in fenugreek spice exhibit antioxidant and antiinflammatory activities. Food Chemistry. 131, 1187-1192, 2012.
Y. Liu, D. Singh and M. G. Nair. Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties. Journal of Functional Foods. 4, 116-121, 2012.
K.P. McCook-Russell, M. G. Nair, P. C. Facey and C. S. Bowen-Forbes. Nutritional and nutraceutical comparison of Jamaican Psidium cattleianum (strawberry guava) and Psidium guajava (common guava) fruits. Food Chemistry. 134, 1069-1073, 2012.
J. Bolleddula, W. Fitch, S. K. Vareed and M. G. Nair. Identification of metabolites in Withania somnifera fruits by liquid chromatography and high resolution mass spectrometry. Rapid Communication in Mass Spectrometry. 26, 1277-1290, 2012.
Y. Liu and M. G. Nair. Curcuma longa and Curcuma mangga leaves exhibit functional food property. Food Chemistry. 135, 634-640, 2012.
S. van Nocker, G. Berry, J. Najdowski, P. Forsline, M. Ordidge, M. Luffman, R. Michelutti, N. Smerirat, R. Beaudry and M. G. Nair. Genetic diversity of red-fleshed apples (Malus). Euphytica. 185, 281-293, 2012.
Z. Zhou, M. G. Nair and K.J. Claycombe. Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin. Phytomedicine. 19, 878-881, 2012.
R. H. C. Nebie, Y. Liu and M. G. Nair. Organic ginger (Zingiber officianlis) inhibits COX-1 and -2 enzymes and lipid peroxidation. Journal of West African Chemical Society. 33, 44-51, 2012.
P. Shukla, S. Walia, V. Ahluwalia, B. S. Parmar and M. G. Nair. Alkanoates of natural alkanediols against plant pathogenic fungi Rhizoctonia solani Kuehn and Sclerotium rolfsii Sacc. Natural Product Communications. 7, 1219-1222, 2012.
C. Zhang, R. E. Schutzki, M.G. Nair. Antioxidant and antiinflammatory compounds in the popular landscape plant Berberis thunbergii var. atropurpurea. Natural Product communications. 8, 165-168, 2013.
Y. Liu, S.S. Roy, R.H.C. Nebie, Y. Zhang and M.G. Nair. Functional food quality of Curcuma caesia, Curcuma zedoaria and Curcuma aeruginosa endemic to northeastern India. Plant Foods for Human Nutrition. 68, 72-77, 2013.
T.D. Miles, C. Vandervoort, M.G. Nair and A.C. Schilder. Characterization and biological activity of flavonoids from ripe fruit of an anthracnose-resistant blueberry cultivar. Physiological and Molecular Plant Pathology, 83, 8-16, 2013.
C. Zhang, S. A. Aldosari, P.S.P. Vidyasagar, K. M. Nair and M. G. Nair. Chemistry of Ajwa date fruit and its health-benefits as indicated by antioxidant and anti-inflammatory activities. J. Agric. Food Chemistry. 61, 5834-5840, 2013.
S. Ali, C. Zhang, A. A. Mohamed, F. K. EL-Baz , A. K. Hegazy, M. A. Kord, and M. G. Nair. Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzymes inhibition and antiproliferative activity. Natural Product Communications. 8, 1365-1366, 2013.
S. K. Vareed, A. K. Bauer, K. M. Nair, Y. Liu, B. Jayaprakasam and M. G. Nair. Blood brain barrier permeability of bioactive withanamides present in Withania somnifera fruit extract. Phytotherapy Research. 28, 1260-1264, 2014.
C. Zhang, A. Dissanayake, K. Kevseroğlu and M. G. Nair. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry. 167, 24-29, 2015.
M. G. Nair, N. Seenivasan, Y. Liu, R.M. Feick, Z-T-Z. Maung and H. Melakeberhan. Leaf constituents of Curcuma spp. suppress Meloidogyne hapla and increase bacterial-feeding nematodes. Nematology. 17, 353-361, 2015.
C. Zhang, S. A. Aldosari, P.S.P. V. Vidyasagar, P. Shukla and M. G. Nair. Determination of the variability of sugars in date fruit varieties by HPLC. Journal of Plantation Crops. 43, 53-61, 2015.
C. Zhang, E. Jayasree, P. Suresh Kumar and M. G. Nair. Antioxidant and antiinflammatory compounds in nutmeg (Myristica fragrans) pericarp as determined by in vitro assays. Natural Product Communications. 10(8), 1399-1402, 2015.
G. Kambou and M. G. Nair. Citec soap: A new additive for Cassia nigricans and Capsicum annum aqueous extracts to control white flies (Bemisia tabaci, Homoptera, Aleyrodidae) and Helicoverpa armigera (Lepidoptera, Noctuidae) on tomato in Burkina Faso. International Journal of Agricultural Innovations and Research. 3, 1807-1813, 2015.
C. Zhang, A. Dissanayake and M. G. Nair. Functional food property of honey locust (Gleditsia triacanthos) flowers. Journal of Functional Foods. 18, 266-274, 2015.
C. Zhang, W. A. Khan, J. Bakht and M. G. Nair. New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chemistry. 196, 726-732, 2016.
A. A. Dissanayake, B. E. Bejcek, C. Zhang and M.G. Nair. Sesquiterpenoid Lactones in Tanacetum huronense Inhibit Human Glioblastoma Cell Proliferation. Natural Product Communications. 11, 579-582, 2016.
Q. Li, C. Zhang, A. A. Dissanayake, Q. Gao and M. G. Nair. Chinese Yam, a popular starchy food, exhibited antiinflammatory activity as shown by cyclooxygenase enzyme inhibition. Natural Product Communications. 11, 579-582, 2016.
R.G. Reyes and M. G. Nair. Lignolytic and leaf litter degrading mushrooms from the Philippines with antioxidant activities. International journal of Pharmaceutical Research and Allied Sciences. 5, 67-74, 2016.
A. A. Dissanayake, C. M. Wagner and M. G. Nair. Chemical Characterization of Lipophilic Constituents in the Skin of Migratory Adult Sea Lamprey from the Great Lakes Region. PLOS ONE | DOI:10.1371/journal.pone.0168609 December 19, 2016.
J. A. Mmongoyo, M. G. Nair, J. E. Linz, F. Wu, A. Dissanayake, C. Zhang, J. K. Mugula and G. M. Strasburg. Bioactive compounds in Diospyros mafiensis roots inhibit growth, sporulation and aflatoxin production by Aspergillus flavus and Aspergillus parasiticus. World Mycotoxin Journal. In Press. DOI 10.3920/WMJ2016.2017.
J. A. Mmongoyo, F. Wu, J. E. Linz, M. G. Nair, J. K. Mugula and G. M. Strasburg. Aflatoxin levels in sunflower seeds and cakes collected from micro- and small-scale sunflower oil processors in Tanzania. PLOS ONE. doi.org/10.1371/journal.pone.0175801, April 2017.
A. A. Dissanayake, B. A.H. Ameen and M. G. Nair. Lipid peroxidation and cyclooxygenase enzyme inhibitory compounds from Prangos haussknechtii. J. Natural Products. 80, 2472-2477, 2017.
A. A. Dissanayake, C. Zhang, M. A. A. Gabor and M. G. Nair. Salicylic glycosides in Salix mucronata with antioxidant and anti-inflammatory activities. Natural Product Communications. 12, 1755-1758, 2017.
C. Zhang, S. A. Aldosari, P.S.P.V. Vidyasagar,P. Shukla, and M. G. Nair. Health-benefits of date fruits produced in Saudi Arabia based on in vitro antioxidant, antiinflammatory and human tumor cell proliferation inhibitory assays. Journal of the Saudi Society of Agricultural Sciences. 16, 287-293, 2017.
A. A. Dissanayake, C. Zhang, G. L. MIlls and M. G. Nair. Cultivated maitake mushroom demonstrated functional food quality as determined by in vitro bioassays. Journal of Functional Foods. 44, 79-85, 2018.
W. Khan, J. Bakht, M. G. Nair. M. N. Uddin and M. Shafi. Extraction and isolation of important bioactive compounds from the fruit of Physalis ixocarpa. Pak. J. Pharm. Sci. 31 (6), 2463-2469, 2018.
A. C. Dametto, N. Boralle, C-R. Zhang, D. H. S. Silva and M. G. Nair. Leaves of Eugenia brasiliensis used as a folk medicine contain cyclooxygenase enzyme and lipid peroxidation inhibitory compounds. Natural Product Communications. 13 (8), 977-980, 2018.
A. Dissanayake, C. Michael Wagner and M. G. Nair. Nitrogenous compounds characterized in the deterrent skin of migratory adult sea lamprey from the Great Lakes region. PLOS ONE. https://doi.org/10.1371/journal.pone.0217417 May 23, 2019.
A. A. Dissanayake, G. L. Mills, G. Bonito, B. Rennick and M. G. Nair. Chemical Composition, Anti-inflammatory and Antioxidant Activities of extracts from Cultivated Morel Mushrooms (Ascomycota, Pezizales). International Journal of Medicinal Mushrooms. 1-11, 2021.
A. Dissanayake, C. M. Wagner and M. G. Nair. Evaluation of health benefits of sea lamprey (Petromyzon marinus) isolates using in vitro antiinflammatory and antioxidant assays. PLOS ONE 16(11): e0259587. https://doi.org/10.1371/journal.pone.0259587 PLOS ONE. 2021.
A. Dissanayake, Juma A. Mmongoyo and M. G. Nair. Zanzibar yam (Dioscorea sansibarensis Pax) isolates exhibit cyclooxygenase enzyme and lipid peroxidation inhibitory activities. Natural Product Research. 2022. http://dx.doi.org/10.1080/14786419.2021.2004598.
J. Gao, A. A. Dissanayake, C. Xiao, M. Zhao and M. G. Nair. The edible cultivated seaweed Laminaria japonica contains cholesterol analogues that inhibit lipid peroxidation and cyclooxygenase enzymes. PLOS ONE. 1-12, https://doi.org/10.1371/journal.pone.0259587, 2022.
A. Dissanayake, K. Georges and M. G. Nair. Cyclooxygenase enzyme and lipid peroxidation inhibitory terpenoids and steroidal compounds as major constituents in Cleome viscosa leaves. Planta Medica. 2022. DOI 10.1055/a-1728-2347. https://doi.org/10.1055/a-1728-2347 (supplementary material).
L. Mensch, A. A. Dissanayake, M. G. Nair and C. M. Wagner. Progress toward chemical identification of the sea lamprey (Petromyzon marinus) alarm cue. Journal of Chemical Ecology. 2022. https://doi.org/10.1007/s10886-022-01384-0 or https://link.springer.com/content/pdf/10.1007/s10886-022-01384-0.pdf.
L. Mensch, A. A. Dissanayake, M. G. Nair and C. M. Wagner. The effect of putrescine on space use and activity in sea lamprey (Petromyzon marinus). Scientific Reports. 2022. https://doi.org/10.1038/s41598-022-22143-x or https://www.nature.com/articles/s41598-022-22143-x.pdf.